Targeted Network Meeting
The state of the art; biomarkers for the prediction of suicidal behaviour

Every year close to 800 000 people take their own life and there are many more people who attempt suicide, however, a large proportion of suicidal behaviour can be prevented. Early recognition of suicidality and reliable evaluation of suicide risk are crucial for the clinical prevention of suicide. Psychiatrists and other mental health professionals have always longed for reliable and precise tools to predict suicidal behaviour, which could support their clinical practice, allow them to concentrate resources on patients that really need them, and backup their clinical judgement, in case of eventual legal problems. Today, several measurement tools of suicide risk exist, including psychometric and biological measurements. Some of these tools have been extensively studied and measures of their sensitivity and specificity have been estimated. However, the low precision of the predictions make the current tools insufficient from the clinical perspective and they contribute very little information that is not already gained in a standard clinical interview. Clinically useful predictive models need, for example, to identify non-suicidal individuals in known high-risk groups (e.g. those with depression, schizophrenia or even suicidal thoughts and plans). In order to be useful, however, the approximate probability that a suicidal event might happen in the future is not sufficient to significantly change clinical routines and practices. Currently, the confidence intervals of this approximation are rather large, questioning the usefulness of all available tools. This TNM will be dedicated to an overview and discussion on the most recent research about biomarkers for suicidal behaviour, including genetic biomarkers, non-genetic biological biomarkers and clinical biomarkers. We expect that through exchange of knowledge and discussions during the meeting, new strategies to design studies for suicide risk evaluation could emerge. Possibilities and opportunities for grant applications in the topic will also be sought
coordinators: Danuta Wasserman, Sweden
Vladimir Carli, Sweden
Wednesday 10 October 2018

08:00 - 15:00

Room 120
08:00 - 09:45 Genetic biomarkers for suicidal behaviour
 speaker: J. John Mann, United States
 discussant: Pilar A. Saiz, Spain
09:30 - 09:45Discussion
09:45 - 10:15Coffee Break
10:15 - 12:00Immunological bio-markers for suicidal behaviour
 speaker: Alan Apter, Israel
 discussant: Philippe Courtet, France
11:45 - 12:00Discussion
12:00 - 13:00Lunch
13:00 - 14:45Clinical biomarkers for suicidal behaviour
 speaker: Alessandro Serretti, Italy
 discussant: Judit Balazs, Hungary
14:30 - 14:45Discussion
14:45 - 15:00General discussion and closing by meeting coordinators